Gene mapping and chromosome 19.
نویسندگان
چکیده
منابع مشابه
Human insulin receptor gene. Data supporting assignment to chromosome 19.
Somatic cell hybrid clones constructed by crossing human skin fibroblasts with mouse L cells have been examined for expression of human insulin receptors, using a monoclonal antibody directed against the human insulin receptor. Data obtained in this study support the assignment of the human gene for the insulin receptor to chromosome 19.
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Functional gene description: The sensory systems reponsible for maintenance of equilibrium and balance are ontained within the vestibular portion of the inner ear. The toconial complex, an extracellular structure containing igh-density particles called otoconia, renders the receptor ells of the sensory macular epithelium responsive to gravity. he major matrix protein (otoconin-90, OC90) account...
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The rat beige (bg) autosomal recessive gene, causing Chediak-Higashi Syndrome (CHS) in rat, was mapped on Chr 17 by using synteny of rat to mouse and humans. The linkage between the beige gene and PCR-amplified microsatellite markers in (DA-bg x BN)F1 x DA-bg backcross progeny was analysed. The recombination frequency was 9.5% between Prl and Acrm and 19.1% between Acrm and bg. The proposed ord...
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Although single chi-square analysis of the North American Rheumatoid Arthritis Consortium (NARAC) data identifies many single-nucleotide polymorphisms (SNPs) with p-values less than 0.05, none remain significant after Bonferroni correction. In contrast, CHROMSCAN evades heavy Bonferroni correction and auto-correlation between SNPs by using composite likelihood to model association across all ma...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1986
ISSN: 1468-6244
DOI: 10.1136/jmg.23.1.2